Synapses in Mice Promotes Regeneration of Neuromuscular MicroRNA - 206 Delays
نویسنده
چکیده
. clicking here colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others . here following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles (this information is current as of March 29, 2010 ): The following resources related to this article are available online at www.sciencemag.org http://www.sciencemag.org/cgi/content/full/326/5959/1549 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/326/5959/1549/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://www.sciencemag.org/cgi/content/full/326/5959/1549#related-content http://www.sciencemag.org/cgi/content/full/326/5959/1549#otherarticles , 19 of which can be accessed for free: cites 34 articles This article 1 article(s) on the ISI Web of Science. cited by This article has been http://www.sciencemag.org/cgi/content/full/326/5959/1549#otherarticles 2 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/medicine Medicine, Diseases : subject collections This article appears in the following
منابع مشابه
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of motor neurons, denervation of target muscles, muscle atrophy, and paralysis. Understanding ALS pathogenesis may require a fuller understanding of the bidirectional signaling between motor neurons and skeletal muscle fibers at neuromuscular synapses. Here, we show that a key regulator of this signaling is...
متن کاملmicroRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice.
Skeletal muscle injury activates adult myogenic stem cells, known as satellite cells, to initiate proliferation and differentiation to regenerate new muscle fibers. The skeletal muscle-specific microRNA miR-206 is upregulated in satellite cells following muscle injury, but its role in muscle regeneration has not been defined. Here, we show that mi...
متن کاملThe Role of Muscle microRNAs in Repairing the Neuromuscular Junction
microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote maintenance and repair of the neuromuscular junction (NMJ); in mutant mice lacking miR-206, reinnervation is impaired following nerve injury and loss of NMJs is accelerated in a...
متن کاملExpression of Muscle-Specific MiRNA 206 in the Progression of Disease in a Murine SMA Model
Spinal muscular atrophy (SMA) is a severe neuromuscular disease, the most common in infancy, and the third one among young people under 18 years. The major pathological landmark of SMA is a selective degeneration of lower motor neurons, resulting in progressive skeletal muscle denervation, atrophy, and paralysis. Recently, it has been shown that specific or general changes in the activity of ri...
متن کاملMicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse.
MicroRNAs are highly conserved, noncoding RNAs involved in posttranscriptional gene silencing. MicroRNAs have been shown to be involved in a range of biological processes, including myogenesis and muscle regeneration. The objective of this study was to test the hypothesis that microRNA expression is altered in dystrophic muscle, with the greatest change occurring, of the muscles examined, in th...
متن کامل